Does Azathioprine Interact With Sulfamethoxazole Trimethoprim?
Use with Other Agents Affecting Myelopoesis Drugs which may affect leukocyte production, including co-trimoxazole, may lead to exaggerated leukopenia, especially in renal transplant recipients.
Severity: Minor
Severity basis: drug interactions section. Combining Azathioprine (Immunosuppressant) and Sulfamethoxazole Trimethoprim (Sulfonamide antibiotic) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Use with Other Agents Affecting Myelopoesis Drugs which may affect leukocyte production, including co-trimoxazole, may lead to exaggerated leukopenia, especially in renal transplant recipients.
Source: FDA structured product labeling (set_id 040d010a-b1b2-4db7-905d-8aa7f1bab0cd).
Sulfamethoxazole Trimethoprim
Sulfonamide antibiotic
Brands: Bactrim, Septra
View Sulfamethoxazole Trimethoprim safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.