Does Cyanocobalamin Interact With Metformin?
( 5.1 ) Vitamin B 12 Deficiency: Metformin may lower vitamin B12 levels.
Severity: Minor
Severity basis: warnings section. Combining Cyanocobalamin (Vitamin B12 supplement) and Metformin (Biguanide antidiabetic) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
( 5.1 ) Vitamin B 12 Deficiency: Metformin may lower vitamin B12 levels.
Source: FDA structured product labeling (set_id 011de1a5-1ac0-4831-9e8d-26ec79ba2205).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.