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    HomeMedication GuideAcetaminophen Safety
    Analgesic / antipyretic

    Acetaminophen: What to Know Before You Take It

    Also sold as Tylenol

    What Acetaminophen Is Used For

    Uses temporarily relieves minor aches and pains due to: headache the common cold backache minor pain of arthritis toothache muscular aches premenstrual and menstrual cramps temporarily reduces fever

    Warnings

    Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Do not use if you are allergic to acetaminophen or any of the inactive ingredients in this product with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. Ask a doctor before use if you have liver disease. Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin. Stop use and ask a doctor if new symptoms occur pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

    Acetaminophen Drug Interactions (6)

    Acetaminophen + Carbamazepine
    In addition, carbamazepine causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib…
    Moderate interaction
    Acetaminophen + Finasteride
    7.2 Other Concomitant Therapy Although specific interaction studies were not performed, finasteride doses of 1 mg or more were concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, α-blockers, analgesics, angiotensin-converting enzyme (ACE) inhibitors, anticonvulsants, benzodiazepines, beta blockers, calcium-channel blockers, cardiac nitrates, diuretics, H 2 antagonists, HMG-CoA reductase inhibitors, prostaglandin synthetase inhibitors (also referred to as NSAIDs), …
    Minor interaction
    Acetaminophen + Metoclopramide
    digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).
    Minor interaction
    Acetaminophen + Oseltamivir
    7.2 Drugs Without Clinically Significant Drug Interaction with Oseltamivir Phosphate for Oral Suspension No dose adjustments are needed for either oseltamivir or the concomitant drug when coadministering oseltamivir with amoxicillin, acetaminophen, aspirin, cimetidine, antacids (magnesium and aluminum hydroxides and calcium carbonates), rimantadine, amantadine, or warfarin [see Clinical Pharmacology (12.3) ] .
    Minor interaction
    Acetaminophen + Valproic Acid
    Drugs for which either no interaction or a likely clinically unimportant interaction has been observed Acetaminophen Valproate had no effect on any of the pharmacokinetic parameters of acetaminophen when it was concurrently administered to three epileptic patients.
    Minor interaction
    Acetaminophen + Warfarin
    Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin.
    Minor interaction

    Check Acetaminophen against your full medication list in our free Interaction Checker

    Most-Reported Side Effects

    Based on 668,254 reports in the FDA Adverse Event Reporting System (FAERS). Reports do not prove the drug caused the effect.

    drug ineffective51,449pain48,851fatigue44,903nausea40,979overdose40,500drug dependence39,159off label use38,609headache37,904death36,202diarrhoea31,598dyspnoea30,109toxicity to various agents27,575

    Explore full Acetaminophen safety data in our free FDA Safety Explorer

    FDA Recalls (showing 12 of 20)

    Class IIOngoingDec 16, 2025

    Failed Tablet/Capsule Specification: There is a potential for the imprint to be missing on tablets.

    Recalling firm: SpecGx, LLC

    Class IIOngoingDec 16, 2025

    Failed Tablet/Capsule Specification: There is a potential for the imprint to be missing on tablets.

    Recalling firm: SpecGx, LLC

    Class IIOngoingOct 21, 2025

    Defective Container

    Recalling firm: Kenvue Brands LLC

    Class IIOngoingAug 20, 2025

    Discoloration

    Recalling firm: Baxter Healthcare Corporation

    Class IIOngoingMay 22, 2025

    cGMP deviations: Due to confirmed consumer complaints received with the observation of tablet discoloration (brown surface on tablets).

    Recalling firm: Aurobindo Pharma USA Inc

    Class IIOngoingMar 13, 2025

    CGMP Deviations

    Recalling firm: Glenmark Pharmaceuticals Inc., USA

    Class IITerminatedNov 14, 2024

    CGMP Deviations: Released product should have been rejected.

    Recalling firm: LNK International, Inc.

    Class IIIOngoingSep 25, 2024

    Crystallization: Lack of uniformity - a change in texture, chunky, grainy, and small crystal substances inside the bottles.

    Recalling firm: Denison Pharmaceuticals, LLC

    Class IIIOngoingSep 25, 2024

    Crystallization: Lack of uniformity - a change in texture, chunky, grainy, and small crystal substances inside the bottles.

    Recalling firm: Denison Pharmaceuticals, LLC

    Class IOngoingJul 11, 2024

    Labeling: Missing Label - some bottles are missing the the manufacturers label that includes the drug facts information.

    Recalling firm: Aurobindo Pharma USA Inc

    Class IOngoingJul 8, 2024

    Labeling: Label Mix-up: a bag of Dexmedetomidine HCl in 0.9% Sodium Chloride Injection was found inside an overwrap labeled Acetaminophen Injection 1,000 mg per 100 mL (10 mg/mL)

    Recalling firm: Hikma Pharmaceuticals USA Inc.

    Class ITerminatedJun 21, 2024

    Labeling: Label Mix-Up: Some bottles of Acetaminophen Extra Strength 500 mg tablets were incorrectly labeled with the drug facts label for Aspirin 81 mg tablets.

    Recalling firm: A-S Medication Solutions LLC

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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