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    HomeMedication GuideDiphenhydramine Safety
    First-generation antihistamine

    Diphenhydramine: What to Know Before You Take It

    Also sold as Benadryl

    What Diphenhydramine Is Used For

    Uses temporarily relieves these symptoms due to hay fever or other respiratory allergies: ■ sneezing ■ itching of the nose or throat ■ runny nose ■ itchy watery eyes ■temporarily relieves these symptoms due to the common cold: ■ sneezing ■ runny nose

    Warnings

    Warnings Do not use ■ with any other product containing diphenhydramine, even one used on skin ■ to make a child sleepy Ask a doctor before use if the child has ■ glaucoma ■ a breathing problem such as chronic bronchitis

    Most-Reported Side Effects

    Based on 195,250 reports in the FDA Adverse Event Reporting System (FAERS). Reports do not prove the drug caused the effect.

    off label use18,865fatigue17,722nausea16,264headache15,547drug ineffective14,926pain13,890dyspnoea12,039pruritus10,825arthralgia10,162diarrhoea9,989infusion related reaction9,960rash9,855

    Explore full Diphenhydramine safety data in our free FDA Safety Explorer

    FDA Recalls (4)

    Class IITerminatedApr 13, 2022

    cGMP deviations: Temperature abuse

    Recalling firm: Mckesson Medical-Surgical Inc. Corporate Office

    Class IITerminatedMar 15, 2021

    CGMP Deviations: Intermittent exposure to temperature excursion during storage.

    Recalling firm: Cardinal Health Inc.

    Class IITerminatedJul 10, 2019

    Microbial contamination of non-sterile product

    Recalling firm: LNK International, Inc.

    Class IIITerminatedFeb 26, 2014

    Subpotent Drug: This lot is being recalled because of out-of-specification test results for Diphenhydramine citrate.

    Recalling firm: Pfizer Us Pharmaceutical Group

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Considering Diphenhydramine? Talk to a Provider First

    Our board-certified providers can review whether Diphenhydramine is right for you, check it against your current medications, and prescribe online when appropriate.