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    HomeMedication GuideHydralazine Safety
    Vasodilator

    Hydralazine: What to Know Before You Take It

    Also sold as Apresoline

    What Hydralazine Is Used For

    INDICATIONS AND USAGE Essential hypertension, alone or as an adjunct.

    Warnings

    WARNINGS ​ In a few patients hydrALAZINE may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis. In such patients hydrALAZINE should be discontinued unless the benefit-to-risk determination requires continued antihypertensive therapy with this drug. Symptoms and signs usually regress when the drug is discontinued but residua have been detected many years later. Long-term treatment with steroids may be necessary. (See PRECAUTIONS, Laboratory Tests .)

    Contraindications

    CONTRAINDICATIONS Hypersensitivity to hydrALAZINE; coronary artery disease; mitral valvular rheumatic heart disease.

    Most-Reported Side Effects

    Based on 29,495 reports in the FDA Adverse Event Reporting System (FAERS). Reports do not prove the drug caused the effect.

    chronic kidney disease2,854acute kidney injury2,671renal failure2,133end stage renal disease1,605dyspnoea1,603fatigue1,597diarrhoea1,464nausea1,409drug ineffective1,377hypertension1,362death1,360off label use1,235

    Explore full Hydralazine safety data in our free FDA Safety Explorer

    FDA Recalls (3)

    Class IITerminatedJan 26, 2022

    CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.

    Recalling firm: CARDINAL HEALTHCARE

    Class IITerminatedMar 8, 2017

    Temperature Abuse: Certain pieces of these lots distributed by McKesson Medical Surgical Inc. were inadvertently stored refrigerated rather than the labeled room temperature recommendation.

    Recalling firm: Mckesson Medical Surgical

    Class IIITerminatedJul 28, 2015

    Incorrect Expiration Date: The "11/06" expiration date printed on the tray (secondary packaging) is incorrect (it should be 11/2016)

    Recalling firm: Fresenius Kabi USA, LLC

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Considering Hydralazine? Talk to a Provider First

    Our board-certified providers can review whether Hydralazine is right for you, check it against your current medications, and prescribe online when appropriate.