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    HomeMedication GuideKPV Tripeptide safety
    Alpha-MSH C-terminal tripeptide — research compoundInvestigational / Not FDA-Approved

    KPV: Patient Information & Safety Notes

    Also known as Lys-Pro-Val

    Other names: lys-pro-val, -msh-c-terminus-tripeptide

    KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (α-MSH). It has potent anti-inflammatory properties in preclinical models and has been studied for inflammatory bowel disease and skin inflammatory conditions. It is NOT FDA-approved.

    NOT FDA-approved. KPV has been studied in preclinical models but lacks adequate human clinical trials establishing safety or effectiveness.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What KPV Tripeptide is used for

    • Investigated in research settings for inflammatory bowel conditions and inflammatory skin conditions

    Taking this medicine

    How it is administered

    • Subcutaneous injection
    • Oral capsule (for gut-targeted effects)

    Read before you decide

    Risks and precautions

    Risks and warnings

    • Injection site irritation
    • Mild headache, fatigue
    • Human safety profile not established in large-scale clinical trials

    Who should not take it

    • Active infection (melanocortin pathway modulation may affect immune responses)
    • Pregnancy or breastfeeding (insufficient safety data)
    • Autoimmune disease requiring immunosuppression (immune modulation precaution)

    Common questions

    Patient questions

    Is KPV approved for inflammatory bowel disease?

    No. KPV is not FDA-approved for IBD or any condition. It is a research compound with preclinical (animal) data only. Individuals with IBD should work with a gastroenterologist for evidence-based treatments such as aminosalicylates, corticosteroids, biologics, or immunomodulators.

    Is KPV the same as alpha-MSH?

    KPV is the three-amino-acid C-terminal fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (α-MSH). It shares some anti-inflammatory properties with the full peptide. Neither is FDA-approved for human use as a standalone therapeutic agent.

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    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.