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    HomeMedication GuideMethylene Blue safety
    Phenothiazine dye / oxidation-reduction agentCompounded / Off-Label

    Methylene Blue: Patient Information & Safety Notes

    Also known as MB, Provayblue

    Other names: methylthioninium-chloride, mb, provayblue

    Methylene blue is a synthetic compound with diverse pharmacological actions. It is FDA-approved for methemoglobinemia. It has been investigated off-label for anti-aging, cognitive support, and as a mitochondrial electron carrier. Low-dose methylene blue is available in compounded preparations for off-label uses.

    FDA-approved as Provayblue (injectable) for methemoglobinemia (acquired or hereditary). Off-label use for cognitive support, anti-aging, and antidepressant effects is investigational and not FDA-approved for those indications. Oral compounded preparations are available.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What Methylene Blue is used for

    • FDA-approved: methemoglobinemia
    • Off-label/investigational: anti-aging, cognitive support, mitochondrial function

    Taking this medicine

    How it is administered

    • Subcutaneous injection (compounded)
    • Oral (compounded)

    Read before you decide

    Risks and precautions

    Risks and warnings

    • Headache, nausea, diarrhea
    • Urine discoloration (blue-green — expected and harmless)
    • Serotonin syndrome risk with concurrent serotonergic medications

    Who should not take it

    • Concurrent SSRI, SNRI, or MAO inhibitor use (serotonin syndrome risk — potentially serious)
    • G6PD deficiency (hemolytic anemia risk)
    • Pregnancy

    Common questions

    Patient questions

    Is methylene blue safe with antidepressants?

    Methylene blue has MAO-inhibiting properties and can cause serotonin syndrome when combined with SSRIs, SNRIs, or other serotonergic drugs. This is a potentially serious interaction. Inform your provider of all medications before starting methylene blue.

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    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Have medication questions?

    A licensed OmniRx provider can review your health history and medication list. Availability and treatment options are determined individually.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.