MOTS-C: Patient Information & Safety Notes
Other names: mitochondrial-open-reading-frame-of-the-12s-rrna-c
MOTS-C is a 16-amino-acid peptide encoded within the 12S rRNA gene of mitochondrial DNA. It has been studied in preclinical models for its role in energy metabolism via AMPK activation. It is NOT approved by the FDA and its human effects are not established.
In plain language
What MOTS-C is used for
- Studied in preclinical research for a possible role in mitochondrial signaling
Taking this medicine
How it is administered
- Subcutaneous injection
Read before you decide
Risks and precautions
Risks and warnings
- Nausea
- Injection site irritation
- Human safety profile not established
Who should not take it
- Active or past malignancy
- Pregnancy or breastfeeding
Common questions
Patient questions
Is MOTS-C FDA-approved?
No. MOTS-C is a research compound with no FDA approval. Human clinical evidence is lacking. It should not be confused with established metabolic medications.
Related medications
Explore treatment hubs
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Sources & References
Learn more about where our data comes from and how we write and review medical content.