Semax: Patient Information & Safety Notes
Also known as ACTH(4-7)PGP, Met-Glu-His-Phe-Pro-Gly-Pro
Other names: acth4-7pgp, met-glu-his-phe-pro-gly-pro
Semax is a synthetic heptapeptide analogue of the ACTH 4-10 fragment with additional Pro-Gly-Pro extension. It has been studied in Russia for cognitive enhancement, neuroprotection, and BDNF stimulation. It is NOT FDA-approved in the United States.
In plain language
What Semax is used for
- Investigated for cognitive enhancement, focus, and neuroprotection (primarily Russian studies)
Taking this medicine
How it is administered
- Intranasal spray
Read before you decide
Risks and precautions
Risks and warnings
- Mild nasal irritation
- Headache, fatigue
- Occasional sleep disturbances
Who should not take it
- Pregnancy
Common questions
Patient questions
Is semax approved in the US?
No. Semax is not FDA-approved in the United States. It is approved in Russia for neurological conditions. US clinical evidence is extremely limited. A licensed provider can recommend evidence-based cognitive and neurological treatments.
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Sources & References
Learn more about where our data comes from and how we write and review medical content.