Patient Portal
    Call:+1 (816) 367-6970
    Trusted by over 10K subscribers
    Free & discreet shipping on all prescriptions
    Affordable pricing with no hidden fees
    FDA-regulated pharmacies
    100% online process
    Trusted by over 10K subscribers
    Free & discreet shipping on all prescriptions
    Affordable pricing with no hidden fees
    FDA-regulated pharmacies
    100% online process
    Trusted by over 10K subscribers
    Free & discreet shipping on all prescriptions
    Affordable pricing with no hidden fees
    FDA-regulated pharmacies
    100% online process
    HomeMedication GuideDesiccated Thyroid Extract / T3 T4 Combination safety
    Combined synthetic or desiccated thyroid hormone (T3 + T4)Compounded / Off-Label

    Thyroid Oral Capsules (T3/T4 Combination): Patient Information & Safety Notes

    Also known as NDT

    Other names: natural-desiccated-thyroid, ndt, compounded-thyroid-t3-t4

    Compounded T3/T4 combination thyroid capsules provide both the active thyroid hormone T3 (liothyronine) and the prohormone T4 (levothyroxine) in a single preparation. Natural desiccated thyroid (NDT) products like NP Thyroid and Armour Thyroid are FDA-approved; custom-ratio compounded preparations are not standardized or FDA-approved.

    FDA-approved desiccated thyroid products (NP Thyroid, Armour Thyroid) contain standardized T3/T4 ratios. Custom-ratio compounded T3/T4 capsules are available through 503A pharmacies but are not FDA-approved as standardized products.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What Desiccated Thyroid Extract / T3 T4 Combination is used for

    • Hypothyroidism (in patients who prefer or require combination T3/T4 therapy)

    Taking this medicine

    How it is administered

    • Oral capsule

    Read before you decide

    Risks and precautions

    Risks and warnings

    • Elevated heart rate and blood pressure
    • Palpitations, jitteriness
    • Insomnia

    Who should not take it

    • Uncorrected adrenal insufficiency
    • Untreated hyperthyroidism

    Common questions

    Patient questions

    Is compounded T3/T4 better than levothyroxine alone?

    Some patients report improved symptoms on combination T3/T4 therapy. However, large clinical trials have not consistently shown superiority over levothyroxine monotherapy. Compounded custom ratios lack FDA approval and standardization. A licensed provider and endocrinologist can assess whether this is appropriate for you.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Have medication questions?

    A licensed OmniRx provider can review your health history and medication list. Availability and treatment options are determined individually.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.