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    HomeMedication GuideAlprostadil With Papaverine And Phentolamine safety
    Compounded intracavernosal vasoactive combinationCompounded / Off-Label

    Tri-Mix (Trimix): Patient Information & Safety Notes

    Also known as Trimix, Tri Mixx, TriMix injectable

    Other names: tri-mixx, trimix-injectable

    Trimix is a compounded intracavernosal injection containing three vasoactive agents: alprostadil (a prostaglandin, FDA-approved as Caverject), papaverine (a vasodilator), and phentolamine (an alpha-adrenergic blocker). The combination product is compounded and not FDA-approved as a fixed combination, but it is a well-established clinical practice for erectile dysfunction refractory to oral PDE5 inhibitors.

    Alprostadil (Caverject) is the only component FDA-approved for intracavernosal use in ED. Trimix as a three-drug combination is a compounded preparation widely used in clinical practice for ED, especially when oral medications are ineffective or contraindicated. It is not FDA-approved as a fixed combination.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What Alprostadil With Papaverine And Phentolamine is used for

    • Erectile dysfunction — particularly in patients who do not respond to or cannot use oral PDE5 inhibitors

    Taking this medicine

    How it is administered

    • Penile (intracavernosal) injection

    What's in it

    Ingredients

    AlprostadilPapaverinePhentolamine

    Read before you decide

    Risks and precautions

    Risks and warnings

    • Pain, swelling, bruising at injection site
    • Prolonged erection (priapism — medical emergency if lasting >4 hours)
    • Scarring (Peyronie's disease) with long-term use

    Who should not take it

    • Conditions predisposing to priapism (sickle cell, leukemia)
    • Anatomical deformities of the penis

    Common questions

    Patient questions

    What should I do if a Trimix-induced erection lasts more than 4 hours?

    A prolonged erection (priapism) lasting more than 4 hours is a medical emergency. Seek emergency care immediately. Priapism can cause permanent erectile dysfunction if not treated promptly.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Have medication questions?

    A licensed OmniRx provider can review your health history and medication list. Availability and treatment options are determined individually.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.