Does Buspirone Interact With Lisdexamfetamine?
5.7 Serotonin Syndrome Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
Severity: Minor
Severity basis: warnings section. Combining Buspirone (Azapirone anxiolytic) and Lisdexamfetamine (CNS stimulant (ADHD)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
5.7 Serotonin Syndrome Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
Source: FDA structured product labeling (set_id 0e024b69-567c-4b40-9c3e-a2daec34256c).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Buspirone Interactions
- Buspirone + Fluoxetine(moderate)
- Buspirone + Itraconazole(moderate)
- Buspirone + Amphetamine Dextroamphetamine(minor)
- Buspirone + Citalopram(minor)
- Buspirone + Desvenlafaxine(minor)
- Buspirone + Diltiazem(minor)
- Buspirone + Duloxetine(minor)
- Buspirone + Escitalopram(minor)
- Buspirone + Lithium(minor)
- Buspirone + Mirtazapine(minor)
- Buspirone + Nortriptyline(minor)
- Buspirone + Paroxetine(minor)
- Buspirone + Sertraline(minor)
- Buspirone + Trazodone(minor)
- Buspirone + Venlafaxine(minor)