Does Buspirone Interact With Trazodone?
Examples: triptans, antidepressants (tricyclic and serotonin uptake inhibitors), fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
Severity: Minor
Severity basis: drug interactions section. Combining Buspirone (Azapirone anxiolytic) and Trazodone (Serotonin antagonist/reuptake inhibitor) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Buspirone is a azapirone anxiolytic and Trazodone is a serotonin antagonist/reuptake inhibitor; together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Buspirone and Trazodone, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Examples: triptans, antidepressants (tricyclic and serotonin uptake inhibitors), fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
Source: FDA structured product labeling (set_id 007f38e0-653b-43e4-a1c1-b59997b2762a).
Trazodone
Serotonin antagonist/reuptake inhibitor
Brands: Desyrel, Oleptro
View Trazodone safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Buspirone and Trazodone together?
Buspirone and Trazodone have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How serious is the Buspirone and Trazodone interaction?
It is classified as a minor interaction, based on the FDA label's drug interactions section. A minor interaction is usually limited in effect but is still worth discussing with your care team.
What should I do if I'm taking both Buspirone and Trazodone?
If you have been prescribed both Buspirone and Trazodone, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Buspirone Interactions
- Buspirone + Fluoxetine(moderate)
- Buspirone + Itraconazole(moderate)
- Buspirone + Amphetamine Dextroamphetamine(minor)
- Buspirone + Citalopram(minor)
- Buspirone + Desvenlafaxine(minor)
- Buspirone + Diltiazem(minor)
- Buspirone + Duloxetine(minor)
- Buspirone + Escitalopram(minor)
- Buspirone + Lisdexamfetamine(minor)
- Buspirone + Lithium(minor)
- Buspirone + Mirtazapine(minor)
- Buspirone + Nortriptyline(minor)
- Buspirone + Paroxetine(minor)
- Buspirone + Sertraline(minor)
- Buspirone + Venlafaxine(minor)
Other Trazodone Interactions
- Trazodone + Amiodarone(major)
- Trazodone + Clarithromycin(major)
- Trazodone + Itraconazole(major)
- Trazodone + Aspirin(moderate)
- Trazodone + Digoxin(moderate)
- Trazodone + Phenytoin(moderate)
- Trazodone + Warfarin(moderate)
- Trazodone + Buprenorphine Naloxone(minor)
- Trazodone + Carbamazepine(minor)
- Trazodone + Clopidogrel(minor)
- Trazodone + Codeine(minor)
- Trazodone + Dabigatran(minor)
- Trazodone + Ketoconazole(minor)
- Trazodone + Lithium(minor)
- Trazodone + Morphine(minor)
- Trazodone + Oxycodone(minor)
- Trazodone + Rifampin(minor)
- Trazodone + Rivaroxaban(minor)
- Trazodone + Tramadol(minor)