Does Dexamethasone Interact With Liothyronine?
Glucocorticoids (e.g., Dexamethasone ≥4 mg/day) Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30% with minimal change in serum T4 levels.
Severity: Moderate
Severity basis: drug interactions section (keywords: may decrease). Combining Dexamethasone (Systemic corticosteroid) and Liothyronine (Thyroid hormone (T3)) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Glucocorticoids (e.g., Dexamethasone ≥4 mg/day) Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30% with minimal change in serum T4 levels.
Source: FDA structured product labeling (set_id 0b0f2db9-642d-d84f-b102-b43de34bbe75).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Dexamethasone Interactions
- Dexamethasone + Carbamazepine(moderate)
- Dexamethasone + Hydrocortisone(moderate)
- Dexamethasone + Itraconazole(moderate)
- Dexamethasone + Levothyroxine(moderate)
- Dexamethasone + Aspirin(minor)
- Dexamethasone + Cyclosporine(minor)
- Dexamethasone + Indomethacin(minor)
- Dexamethasone + Ketoconazole(minor)
- Dexamethasone + Phenytoin(minor)
- Dexamethasone + Rifampin(minor)
- Dexamethasone + Warfarin(minor)