Does Dexamethasone Interact With Hydrocortisone?

There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure (see PRECAUTIONS : Drug Interactions: Amphotericin B injection and potassium-depleting agents ).

Severity: Moderate

Severity basis: warnings section (keywords: caution). Combining Dexamethasone (Systemic corticosteroid) and Hydrocortisone (Systemic corticosteroid) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure (see PRECAUTIONS : Drug Interactions: Amphotericin B injection and potassium-depleting agents ).

Source: FDA structured product labeling (set_id 01cfaa3e-5e30-18fa-e063-6394a90a084e).

Dexamethasone

Systemic corticosteroid

Brands: Decadron, Hemady

View Dexamethasone safety profile

Hydrocortisone

Systemic corticosteroid

Brands: Cortef

View Hydrocortisone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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