Does Nitroglycerin Interact With Sildenafil?
4 CONTRAINDICATIONS • Use of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators.
Severity: Contraindicated
Severity basis: contraindications section (keywords: contraindications section). Combining Nitroglycerin (Nitrate vasodilator) and Sildenafil (PDE5 inhibitor) is classified as a contraindicated interaction.
What to Do
This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.
From the FDA Label
4 CONTRAINDICATIONS • Use of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators.
Source: FDA structured product labeling (set_id 041f127e-5166-4484-bc1a-0a373d1187ae).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.