Does Nitroglycerin Interact With Tadalafil?

4 CONTRAINDICATIONS • Use of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators.

Severity: Contraindicated

Severity basis: contraindications section (keywords: contraindications section). Combining Nitroglycerin (Nitrate vasodilator) and Tadalafil (PDE5 inhibitor) is classified as a contraindicated interaction.

What to Do

This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.

From the FDA Label

4 CONTRAINDICATIONS • Use of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators.

Source: FDA structured product labeling (set_id 041f127e-5166-4484-bc1a-0a373d1187ae).

Nitroglycerin

Nitrate vasodilator

Brands: Nitrostat, Nitro-Dur

View Nitroglycerin safety profile

Tadalafil

PDE5 inhibitor

Brands: Cialis, Adcirca

View Tadalafil safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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