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    HomeMedication GuideGW501516 safety
    PPARδ agonist — abandoned research compoundInvestigational / Not FDA-Approved

    GW501516 (Cardarine): Patient Information & Safety Notes

    Also known as Cardarine, GW-501516, GW1516

    Other names: cardarine, gw-501516, gw1516, endurobol

    GW501516 (Cardarine) is a PPARδ agonist that was investigated for dyslipidemia and metabolic disease. Development was ABANDONED by GlaxoSmithKline after preclinical studies showed rapid cancer development in multiple organ systems at therapeutic doses. It is NOT approved by the FDA and is considered hazardous.

    NOT FDA-approved. GW501516 development was halted due to serious carcinogenicity findings in preclinical studies. Its use in humans is not established as safe and poses potential cancer risks. The World Anti-Doping Agency (WADA) has banned it. It is not a recognized medical treatment under any circumstances.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What GW501516 is used for

    • RESEARCH ABANDONED. Not recommended for any use due to serious carcinogenicity risk in preclinical studies.

    Taking this medicine

    How it is administered

    • Oral capsule (research contexts only)

    Read before you decide

    Risks and precautions

    Risks and warnings

    • Cancer development (multiple organ systems in preclinical models — development discontinued for this reason)
    • Elevated glucose, cortisol, liver stress
    • Unknown human safety profile at any dose

    Who should not take it

    • Liver disease
    • Diabetes
    • Pregnancy or breastfeeding

    Common questions

    Patient questions

    Is Cardarine (GW501516) safe?

    No. GW501516 development was abandoned after preclinical studies showed it caused rapid cancer in multiple organ systems. It is not FDA-approved and is considered hazardous. There is no safe dose established for humans. It is banned in competitive sports by WADA. Do not use this compound.

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    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.