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    HomeMedication GuideHydrocortisone Safety
    Systemic corticosteroid

    Hydrocortisone: What to Know Before You Take It

    Also sold as Cortef

    What Hydrocortisone Is Used For

    Uses • temporarily relieves itching associated with minor skin irritations, inflammation, and rashes due to: • eczema • psoriasis • poison ivy, oak, sumac • insect bites • detergents • jewelry • cosmetics • soaps • seborrheic dermatitis • temporarily relieves external anal and genital itching • other uses of this product should only be under the advice and supervision of a doctor

    Warnings

    Warnings For external use only Do not use • in the genital area if you have a vaginal discharge. Consult a doctor. • for the treatment of diaper rash. Consult a doctor. When using this product • avoid contact with the eyes • do not use more than directed unless told to do so by a doctor • do not put directly into the rectum by using fingers or any mechanical device or applicator Stop use and ask a doctor if • condition worsens symptoms persist for more than 7 days or clear up and occur again within a few days, and do not begin use of any other hydrocortisone product unless you have asked a doctor • rectal bleeding occurs Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away (1-800-222-1222).

    Hydrocortisone Drug Interactions (3)

    Check Hydrocortisone against your full medication list in our free Interaction Checker

    Most-Reported Side Effects

    Based on 121,305 reports in the FDA Adverse Event Reporting System (FAERS). Reports do not prove the drug caused the effect.

    off label use14,652drug ineffective13,676fatigue12,266pain10,633arthralgia9,482nausea9,405diarrhoea8,869rash8,761condition aggravated8,725headache8,494dyspnoea8,230pyrexia7,322

    Explore full Hydrocortisone safety data in our free FDA Safety Explorer

    FDA Recalls (showing 12 of 13)

    Class IITerminatedApr 24, 2025

    CGMP Deviations

    Recalling firm: KENIL HEALTHCARE PRIVATE LIMITED

    Class IIITerminatedNov 6, 2023

    Failed Impurities/Degradation Specifications:Out-of-Specification result for Hydrocortisone related impurity and slightly lower than the established level of the Hydrocortisone Assay obtained during stability testing.

    Recalling firm: Taro Pharmaceuticals Inc.

    Class IITerminatedApr 13, 2022

    cGMP deviations: Temperature abuse

    Recalling firm: Mckesson Medical-Surgical Inc. Corporate Office

    Class IITerminatedJan 21, 2022

    cGMP deficiencies

    Recalling firm: Mylan Pharmaceuticals Inc

    Class IITerminatedMar 15, 2021

    CGMP Deviations: Intermittent exposure to temperature excursion during storage.

    Recalling firm: Cardinal Health Inc.

    Class IITerminatedMar 15, 2021

    CGMP Deviations: Intermittent exposure to temperature excursion during storage.

    Recalling firm: Cardinal Health Inc.

    Class IITerminatedJul 11, 2019

    CGMP Deviations: Out of Specification results for either total microbial count or total organic carbon in the purified water utilized in the manufacturing process.

    Recalling firm: US Pharmaceuticals Inc.

    Class IITerminatedJul 11, 2019

    CGMP Deviations: Out of Specification results for either total microbial count or total organic carbon in the purified water utilized in the manufacturing process.

    Recalling firm: US Pharmaceuticals Inc.

    Class IITerminatedJul 11, 2019

    CGMP Deviations: Out of Specification results for either total microbial count or total organic carbon in the purified water utilized in the manufacturing process.

    Recalling firm: US Pharmaceuticals Inc.

    Class IITerminatedJul 11, 2019

    CGMP Deviations: Out of Specification results for either total microbial count or total organic carbon in the purified water utilized in the manufacturing process.

    Recalling firm: US Pharmaceuticals Inc.

    Class IITerminatedJul 11, 2019

    CGMP Deviations: Out of Specification results for either total microbial count or total organic carbon in the purified water utilized in the manufacturing process.

    Recalling firm: US Pharmaceuticals Inc.

    Class IITerminatedDec 7, 2018

    GMP Deviations: Out of specification results for Total Aerobic Microbial count in excipient purified water sample

    Recalling firm: US Pharmaceuticals Inc.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Considering Hydrocortisone? Talk to a Provider First

    Our board-certified providers can review whether Hydrocortisone is right for you, check it against your current medications, and prescribe online when appropriate.