Pinealon / PE 22-28 / Selank Blend: Patient Information & Safety Notes
Also known as Pinealon PE22-28 Selank
Other names: pinealon-pe22-28-selank, cognitive-nasal-blend
A proprietary compounded intranasal spray containing Pinealon (a synthetic tripeptide with purported antioxidant and neuroprotective properties), PE-22-28 (TREK-1 inhibitor research compound), and Selank (synthetic anxiolytic peptide). All three components are research compounds without FDA approval.
In plain language
What Pinealon / PE 22-28 / Selank Nasal Spray Blend is used for
- Multi-target: anxiety reduction, learning and memory, mood stabilization (research compound blend)
Taking this medicine
How it is administered
- Intranasal spray
What's in it
Ingredients
Read before you decide
Risks and precautions
Risks and warnings
- Headache, sleep disturbance or disruption
- Nasal irritation, sneezing
- Potential mood changes or emotional blunting (research compound blend with unknown interactions)
- None of the three components have established human safety profiles for this use
Who should not take it
- Concurrent psychiatric medications (unknown interactions — all three components affect neurological pathways)
- Pregnancy or breastfeeding
- History of seizures (precautionary; neurotransmitter modulation)
Common questions
Patient questions
Is the Pinealon/PE22-28/Selank nasal spray approved?
No. This is a proprietary blend of three research compounds (Pinealon, PE-22-28, Selank). None are FDA-approved for any indication in the United States. Availability is specific to the prescribing and dispensing relationship. Do not assume it is available or safe.
Can this blend treat depression or anxiety?
No. This blend has not been studied in human clinical trials for depression or anxiety. FDA-approved treatments for anxiety and depression include evidence-based medications (SSRIs, SNRIs, etc.) and psychotherapy. Discuss these with a licensed mental health provider.
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Sources & References
Learn more about where our data comes from and how we write and review medical content.