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    HomeMedication GuideSucralfate safety
    Mucosal protectant

    Sucralfate: What to Know Before You Take It

    Also known as Carafate

    A patient-focused safety profile with information from public regulatory sources.

    Reviewed by the OmniRx Health clinical teamLast reviewed Jul 4, 2026

    In plain language

    What Sucralfate is used for

    INDICATIONS AND USAGE Sucralfate tablets are indicated in: Short-term treatment (up to 8 weeks) of active duodenal ulcer. While healing with sucralfate may occur during the first week or two, treatment should be continued for 4 to 8 weeks unless healing has been demonstrated by x-ray or endoscopic examination. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers.

    Read before you decide

    Risks and precautions

    Who should not take it

    CONTRAINDICATIONS Sucralfate tablets are contraindicated in patients with known hypersensitivity reactions to the active substance or to any of the excipients.

    Medication review

    Sucralfate drug interactions

    Sucralfate + FurosemideSimultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive effects of furosemide.Moderate interactionSucralfate + LevofloxacinMonitor prothrombin time, INR and watch for bleeding (7.2) Antidiabetic agents Carefully monitor blood glucose (5.13, 7.3) 7.1 Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins While the chelation by divalent cations is less marked than with other fluoroquinolones, concurrent administration of levofloxacin tablets with antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc may interfere with the…Moderate interactionSucralfate + CiprofloxacinIn all case studies to date (cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine), dosing the concomitant medication 2 hours before sucralfate eliminated the interaction.Minor interactionSucralfate + DigoxinJohn's Wort, sucralfate, sulfasalazine Measure serum digoxin concentrations before initiating concomitant drugs.Minor interactionSucralfate + KetoconazoleDrug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.Minor interactionSucralfate + LansoprazoleSucralfate Clinical Impact: Decreased and delayed absorption of lansoprazole [ see Clinical Pharmacology ( 12.3 )] .Minor interactionSucralfate + LevothyroxineProton Pump Inhibitors Sucralfate Antacids (e.g., aluminum & magnesium hydroxides, simethicone) Gastric acidity is an essential requirement for adequate absorption of levothyroxine.Minor interactionSucralfate + NaproxenAntacids and Sucralfate Clinical Impact: Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of naproxen.Minor interactionSucralfate + PhenytoinDrug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.Minor interactionSucralfate + WarfarinSubtherapeutic prothrombin times with concomitant warfarin and sucralfate therapy have been reported in spontaneous and published case reports.Minor interaction
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    FDA safety data

    Most-reported side effects

    Based on 23,407 FAERS reports. Reports do not prove the drug caused the effect.

    nausea 2,311fatigue 1,767diarrhoea 1,736pain 1,500headache 1,406vomiting 1,386dyspnoea 1,328drug ineffective 1,317off label use 1,309dizziness 1,059weight decreased 1,011abdominal pain 1,001
    Explore full FDA safety data

    Regulatory record

    FDA recalls (4)

    Class IIOngoing · Oct 9, 2025

    CGMP Deviations: The recalling firm filed for Chapter 11 on September 30, 2024. As a result, it cannot monitor the quality program and hence cannot assure that products meet the identity, strength, quality, and purity characteristics that they are purported or represented to possess, rendering the products adulterated.

    Recalling firm: Amerisource Health Services LLC

    Class IIOngoing · Jul 29, 2025

    CGMP Deviations: The recalling firm filed for Chapter 11 in September 2024. As a result, it cannot monitor the quality program and hence cannot assure that products meet the identity, strength, quality, and purity characteristics that they are purported or represented to possess, rendering the products adulterated.

    Recalling firm: Amerisource Health Services LLC

    Class ITerminated · Oct 18, 2023

    Microbial Contamination of Non-Sterile Products: identified as Bacillus cereus.

    Recalling firm: VistaPharm LLC

    Class IITerminated · Aug 30, 2023

    Superpotent/Subpotent single ingredient Drug: Out of Specification Assay results

    Recalling firm: VistaPharm LLC

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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