Does Naproxen Interact With Sucralfate?
Antacids and Sucralfate Clinical Impact: Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of naproxen.
Severity: Minor
Severity basis: drug interactions section. Combining Naproxen (Nonsteroidal anti-inflammatory drug (NSAID)) and Sucralfate (Mucosal protectant) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Naproxen is a nonsteroidal anti-inflammatory drug (nsaid) and Sucralfate is a mucosal protectant; together they are documented as a minor interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Naproxen and Sucralfate, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Antacids and Sucralfate Clinical Impact: Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of naproxen.
Source: FDA structured product labeling (set_id 000155a8-709c-44e5-a75f-cd890f3a7caf).
Naproxen
Nonsteroidal anti-inflammatory drug (NSAID)
Brands: Aleve, Naprosyn
View Naproxen safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Naproxen and Sucralfate together?
Naproxen and Sucralfate have a documented minor interaction. This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
How serious is the Naproxen and Sucralfate interaction?
It is classified as a minor interaction, based on the FDA label's drug interactions section. A minor interaction is usually limited in effect but is still worth discussing with your care team.
What should I do if I'm taking both Naproxen and Sucralfate?
If you have been prescribed both Naproxen and Sucralfate, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Naproxen Interactions
- Naproxen + Aspirin(contraindicated)
- Naproxen + Diclofenac(major)
- Naproxen + Indomethacin(major)
- Naproxen + Cyclosporine(moderate)
- Naproxen + Methotrexate(moderate)
- Naproxen + Warfarin(moderate)
- Naproxen + Celecoxib(minor)
- Naproxen + Digoxin(minor)
- Naproxen + Fluconazole(minor)
- Naproxen + Furosemide(minor)
- Naproxen + Gabapentin(minor)
- Naproxen + Ibuprofen(minor)
- Naproxen + Lithium(minor)
- Naproxen + Meloxicam(minor)
- Naproxen + Propranolol(minor)