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    HomeMedication GuideTesofensine safety
    Triple monoamine reuptake inhibitor (serotonin, norepinephrine, dopamine)Investigational / Not FDA-Approved

    Tesofensine: Patient Information & Safety Notes

    Also known as TE-2187

    Other names: te-2187

    Tesofensine is a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine that has been investigated in clinical trials as an appetite suppressant for obesity. It is NOT approved by the FDA and is not an established medical treatment in the United States.

    NOT FDA-approved. Tesofensine has been studied in Phase 2 clinical trials for obesity but has not completed the regulatory approval process. It is not established as safe or effective for any indication in the United States.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What Tesofensine is used for

    • Investigated in research settings for appetite suppression and weight reduction

    Taking this medicine

    How it is administered

    • Oral capsule

    Read before you decide

    Risks and precautions

    Risks and warnings

    • Nausea, vomiting, diarrhea
    • Nervousness, insomnia
    • Constipation
    • Potential cardiovascular effects (tachycardia, blood pressure changes) — not fully characterized
    • Long-term safety profile not established

    Who should not take it

    • History of myocardial infarction
    • Atrial fibrillation
    • Concurrent use of SSRI antidepressants (serotonin syndrome risk)
    • Pregnancy or breastfeeding

    Common questions

    Patient questions

    Is tesofensine FDA-approved?

    No. Tesofensine is not FDA-approved for any indication. It has been studied in clinical trials for weight loss but has not completed the approval process. It is not established as safe or effective. Discuss any weight management options with a licensed provider who can recommend approved therapies.

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    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.