Does Alprazolam Interact With Mirtazapine?

Examples diazepam, alprazolam, alcohol Drugs that Prolong QTc Interval Clinical Impact The concomitant use of other drugs which prolong the QTc interval with mirtazapine, increase the risk of QTc prolongation and/or ventricular arrhythmias (e.g., Torsades de Pointes).

Severity: Minor

Severity basis: drug interactions section. Combining Alprazolam (Benzodiazepine) and Mirtazapine (Tetracyclic antidepressant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Examples diazepam, alprazolam, alcohol Drugs that Prolong QTc Interval Clinical Impact The concomitant use of other drugs which prolong the QTc interval with mirtazapine, increase the risk of QTc prolongation and/or ventricular arrhythmias (e.g., Torsades de Pointes).

Source: FDA structured product labeling (set_id 0f19ab40-1a30-4ac2-9bd7-c2f8199e29e1).

Alprazolam

Benzodiazepine

Brands: Xanax

View Alprazolam safety profile

Mirtazapine

Tetracyclic antidepressant

Brands: Remeron

View Mirtazapine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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