Does Alprazolam Interact With Fluoxetine?
Monoamine Oxidase Inhibitors (MAOIs): ( 2.9 , 2.10 , 4.1 , 5.2 ) Drugs Metabolized by CYP2D6: Fluoxetine is a potent inhibitor of CYP2D6 enzyme pathway ( 7.7 ) Tricyclic Antidepressants (TCAs): Monitor TCA levels during coadministration with fluoxetine or when fluoxetine has been recently discontinued ( 5.2 , 7.7 ) CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs ( 7.2 ) Benzodiazepines: Diazepam – increased t½, alprazolam - further psychomo…
Severity: Moderate
Severity basis: drug interactions section (keywords: monitor, caution). Combining Alprazolam (Benzodiazepine) and Fluoxetine (SSRI antidepressant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Alprazolam is a benzodiazepine and Fluoxetine is a ssri antidepressant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Alprazolam and Fluoxetine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Monoamine Oxidase Inhibitors (MAOIs): ( 2.9 , 2.10 , 4.1 , 5.2 ) Drugs Metabolized by CYP2D6: Fluoxetine is a potent inhibitor of CYP2D6 enzyme pathway ( 7.7 ) Tricyclic Antidepressants (TCAs): Monitor TCA levels during coadministration with fluoxetine or when fluoxetine has been recently discontinued ( 5.2 , 7.7 ) CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs ( 7.2 ) Benzodiazepines: Diazepam – increased t½, alprazolam - further psychomo…
Source: FDA structured product labeling (set_id 02283de9-6087-45f7-a9ce-3b082ce860de).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Alprazolam and Fluoxetine together?
Alprazolam and Fluoxetine have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Alprazolam and Fluoxetine interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: monitor, caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Alprazolam and Fluoxetine?
If you have been prescribed both Alprazolam and Fluoxetine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Alprazolam Interactions
- Alprazolam + Carbamazepine(moderate)
- Alprazolam + Clarithromycin(moderate)
- Alprazolam + Itraconazole(moderate)
- Alprazolam + Ketoconazole(moderate)
- Alprazolam + Buprenorphine Naloxone(minor)
- Alprazolam + Codeine(minor)
- Alprazolam + Digoxin(minor)
- Alprazolam + Mirtazapine(minor)
- Alprazolam + Morphine(minor)
- Alprazolam + Oxycodone(minor)
- Alprazolam + Phenytoin(minor)
- Alprazolam + Tramadol(minor)
- Alprazolam + Venlafaxine(minor)
- Alprazolam + Warfarin(minor)
Other Fluoxetine Interactions
- Fluoxetine + Olanzapine(contraindicated)
- Fluoxetine + Aspirin(major)
- Fluoxetine + Warfarin(major)
- Fluoxetine + Aripiprazole(moderate)
- Fluoxetine + Atomoxetine(moderate)
- Fluoxetine + Buspirone(moderate)
- Fluoxetine + Carbamazepine(moderate)
- Fluoxetine + Diazepam(moderate)
- Fluoxetine + Duloxetine(moderate)
- Fluoxetine + Glimepiride(moderate)
- Fluoxetine + Insulin Aspart(moderate)
- Fluoxetine + Insulin Glargine(moderate)
- Fluoxetine + Lithium(moderate)
- Fluoxetine + Phenytoin(moderate)
- Fluoxetine + Tramadol(moderate)
- Fluoxetine + Amiodarone(minor)
- Fluoxetine + Amitriptyline(minor)
- Fluoxetine + Bupropion(minor)
- Fluoxetine + Carvedilol(minor)
- Fluoxetine + Clonazepam(minor)
- Fluoxetine + Codeine(minor)
- Fluoxetine + Ketoconazole(minor)
- Fluoxetine + Metoprolol(minor)
- Fluoxetine + Risperidone(minor)
- Fluoxetine + Sertraline(minor)
- Fluoxetine + Tacrolimus(minor)
- Fluoxetine + Venlafaxine(minor)
- Fluoxetine + Zolpidem(minor)