Does Itraconazole Interact With Mirtazapine?

Examples itraconazole, ritonavir, nefazodone Cimetidine Clinical Impact The concomitant use of cimetidine, a CYP1A2, CYP2D6, and CYP3A inhibitor, with mirtazapine may increase the plasma concentration of mirtazapine [see Clinical Pharmacology (12.3) ].

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Itraconazole (Azole antifungal (strong CYP3A4 inhibitor)) and Mirtazapine (Tetracyclic antidepressant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Examples itraconazole, ritonavir, nefazodone Cimetidine Clinical Impact The concomitant use of cimetidine, a CYP1A2, CYP2D6, and CYP3A inhibitor, with mirtazapine may increase the plasma concentration of mirtazapine [see Clinical Pharmacology (12.3) ].

Source: FDA structured product labeling (set_id 0f19ab40-1a30-4ac2-9bd7-c2f8199e29e1).

Itraconazole

Azole antifungal (strong CYP3A4 inhibitor)

Brands: Sporanox, Tolsura

View Itraconazole safety profile

Mirtazapine

Tetracyclic antidepressant

Brands: Remeron

View Mirtazapine safety profile

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This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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