Does Levothyroxine Interact With Nifedipine?
Risk factors for a gastrointestinal obstruction identified from post-marketing reports of nifedipine extended-release tablets (GITS tablet formulation) include alteration in gastrointestinal anatomy (e.g., severe gastrointestinal narrowing, colon cancer, small bowel obstruction, bowel resection, gastric bypass, vertical banded gastroplasty, colostomy, diverticulitis, diverticulosis, and inflammatory bowel disease), hypomotility disorders (e.g., constipation, gastroesophageal reflux disease, i…
Severity: Minor
Severity basis: warnings section. Combining Levothyroxine (Thyroid hormone) and Nifedipine (Calcium channel blocker) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Risk factors for a gastrointestinal obstruction identified from post-marketing reports of nifedipine extended-release tablets (GITS tablet formulation) include alteration in gastrointestinal anatomy (e.g., severe gastrointestinal narrowing, colon cancer, small bowel obstruction, bowel resection, gastric bypass, vertical banded gastroplasty, colostomy, diverticulitis, diverticulosis, and inflammatory bowel disease), hypomotility disorders (e.g., constipation, gastroesophageal reflux disease, i…
Source: FDA structured product labeling (set_id 09a04e5f-d3b0-4ee3-b12d-f74203262179).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Levothyroxine Interactions
- Levothyroxine + Amitriptyline(moderate)
- Levothyroxine + Carbamazepine(moderate)
- Levothyroxine + Dexamethasone(moderate)
- Levothyroxine + Alendronate(minor)
- Levothyroxine + Amiodarone(minor)
- Levothyroxine + Aspirin(minor)
- Levothyroxine + Ferrous Sulfate(minor)
- Levothyroxine + Furosemide(minor)
- Levothyroxine + Liothyronine(minor)
- Levothyroxine + Phenytoin(minor)
- Levothyroxine + Propranolol(minor)
- Levothyroxine + Rifampin(minor)
- Levothyroxine + Semaglutide(minor)
- Levothyroxine + Sertraline(minor)
- Levothyroxine + Sucralfate(minor)