Does Alendronate Interact With Levothyroxine?

7.4 Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] .

Severity: Minor

Severity basis: drug interactions section. Combining Alendronate (Bisphosphonate) and Levothyroxine (Thyroid hormone) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

7.4 Levothyroxine The bioavailability of alendronate was slightly decreased when BINOSTO and levothyroxine were co-administered to healthy subjects [see Clinical Pharmacology (12.3) ] .

Source: FDA structured product labeling (set_id 09765234-01bc-40f7-b9bb-c167056f3909).

Alendronate

Bisphosphonate

Brands: Fosamax, Binosto

View Alendronate safety profile

Levothyroxine

Thyroid hormone

Brands: Synthroid, Levoxyl, Euthyrox

View Levothyroxine safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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