Does Lisinopril Interact With Losartan?
The VA NEPHRON trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate (GFR 30 to 89.9 ml/min), randomized them to lisinopril or placebo on a background of losartan therapy and followed them for a median of 2.2 years.
Severity: Minor
Severity basis: drug interactions section. Combining Lisinopril (ACE inhibitor) and Losartan (Angiotensin receptor blocker (ARB)) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
The VA NEPHRON trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate (GFR 30 to 89.9 ml/min), randomized them to lisinopril or placebo on a background of losartan therapy and followed them for a median of 2.2 years.
Source: FDA structured product labeling (set_id 021831ab-dfeb-40fc-aede-4aa1fbb8d918).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.