Does Lisinopril Interact With Valsartan?
Do not administer Lisinopril tablet USP within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor [see WARNINGS and PRECAUTIONS ( 5.2 )].
Severity: Contraindicated
Severity basis: contraindications section (keywords: contraindications section). Combining Lisinopril (ACE inhibitor) and Valsartan (Angiotensin receptor blocker (ARB)) is classified as a contraindicated interaction.
What to Do
This combination is contraindicated on the FDA label. Do not take these together unless your prescriber explicitly directs it.
From the FDA Label
Do not administer Lisinopril tablet USP within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor [see WARNINGS and PRECAUTIONS ( 5.2 )].
Source: FDA structured product labeling (set_id 021831ab-dfeb-40fc-aede-4aa1fbb8d918).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.