Does Fluconazole Interact With Losartan?

Losartan : Fluconazole inhibits the metabolism of losartan to its active metabolite (E-31 74) which is responsible for most of the angiotensin II-receptor antagonism which occurs during treatment with losartan.

Severity: Minor

Severity basis: drug interactions section. Combining Fluconazole (Azole antifungal) and Losartan (Angiotensin receptor blocker (ARB)) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Losartan : Fluconazole inhibits the metabolism of losartan to its active metabolite (E-31 74) which is responsible for most of the angiotensin II-receptor antagonism which occurs during treatment with losartan.

Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

Fluconazole

Azole antifungal

Brands: Diflucan

View Fluconazole safety profile

Losartan

Angiotensin receptor blocker (ARB)

Brands: Cozaar

View Losartan safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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