Does Olmesartan Interact With Spironolactone?
7.1 Agents Increasing Serum Potassium Concomitant use of olmesartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium.
Severity: Moderate
Severity basis: drug interactions section (keywords: may increase). Combining Olmesartan (Angiotensin receptor blocker (ARB)) and Spironolactone (Potassium-sparing diuretic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
7.1 Agents Increasing Serum Potassium Concomitant use of olmesartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium.
Source: FDA structured product labeling (set_id 04f0107b-4194-4412-9ebb-3219da5a9ac9).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Olmesartan Interactions
Other Spironolactone Interactions
- Spironolactone + Aspirin(moderate)
- Spironolactone + Lithium(moderate)
- Spironolactone + Lovastatin(moderate)
- Spironolactone + Pravastatin(moderate)
- Spironolactone + Valsartan(moderate)
- Spironolactone + Benazepril(minor)
- Spironolactone + Digoxin(minor)
- Spironolactone + Enalapril(minor)
- Spironolactone + Lisinopril(minor)
- Spironolactone + Potassium Chloride(minor)
- Spironolactone + Ramipril(minor)