Does Spironolactone Interact With Valsartan?
7 DRUG INTERACTIONS Potassium-sparing diuretics, potassium supplements or salt substitutes may lead to increases in serum potassium, and in heart failure patients, increases in serum creatinine ( 7.1 ) NSAID use may lead to increased risk of renal impairment and loss of antihypertensive effect ( 7.2 ) Dual inhibition of the renin-angiotensin system : Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.3 ) Lithium : Increases in serum lithium level and lithium toxicity ( 7.4 …
Severity: Moderate
Severity basis: drug interactions section (keywords: increased risk, may increase). Combining Spironolactone (Potassium-sparing diuretic) and Valsartan (Angiotensin receptor blocker (ARB)) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Spironolactone is a potassium-sparing diuretic and Valsartan is a angiotensin receptor blocker (arb); together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Spironolactone and Valsartan, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
7 DRUG INTERACTIONS Potassium-sparing diuretics, potassium supplements or salt substitutes may lead to increases in serum potassium, and in heart failure patients, increases in serum creatinine ( 7.1 ) NSAID use may lead to increased risk of renal impairment and loss of antihypertensive effect ( 7.2 ) Dual inhibition of the renin-angiotensin system : Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.3 ) Lithium : Increases in serum lithium level and lithium toxicity ( 7.4 …
Source: FDA structured product labeling (set_id 00b235b2-a909-4628-b37c-bb02bc5bf7c6).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Spironolactone and Valsartan together?
Spironolactone and Valsartan have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Spironolactone and Valsartan interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: increased risk, may increase). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Spironolactone and Valsartan?
If you have been prescribed both Spironolactone and Valsartan, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Spironolactone Interactions
- Spironolactone + Aspirin(moderate)
- Spironolactone + Lithium(moderate)
- Spironolactone + Lovastatin(moderate)
- Spironolactone + Olmesartan(moderate)
- Spironolactone + Pravastatin(moderate)
- Spironolactone + Benazepril(minor)
- Spironolactone + Digoxin(minor)
- Spironolactone + Enalapril(minor)
- Spironolactone + Lisinopril(minor)
- Spironolactone + Potassium Chloride(minor)
- Spironolactone + Ramipril(minor)