Does Pravastatin Interact With Spironolactone?
Caution should also be exercised if a statin or other agent used to lower cholesterol levels is administered to patients also receiving other drugs (e.g., ketoconazole, spironolactone, cimetidine) that may diminish the levels or activity of steroid hormones.
Severity: Moderate
Severity basis: warnings section (keywords: caution). Combining Pravastatin (HMG-CoA reductase inhibitor (statin)) and Spironolactone (Potassium-sparing diuretic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Pravastatin is a hmg-coa reductase inhibitor (statin) and Spironolactone is a potassium-sparing diuretic; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Pravastatin and Spironolactone, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Caution should also be exercised if a statin or other agent used to lower cholesterol levels is administered to patients also receiving other drugs (e.g., ketoconazole, spironolactone, cimetidine) that may diminish the levels or activity of steroid hormones.
Source: FDA structured product labeling (set_id 01beb7e2-ba01-4f2f-8554-4a8ec0941c9f).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Pravastatin and Spironolactone together?
Pravastatin and Spironolactone have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Pravastatin and Spironolactone interaction?
It is classified as a moderate interaction, based on the FDA label's warnings section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Pravastatin and Spironolactone?
If you have been prescribed both Pravastatin and Spironolactone, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Pravastatin Interactions
Other Spironolactone Interactions
- Spironolactone + Aspirin(moderate)
- Spironolactone + Lithium(moderate)
- Spironolactone + Lovastatin(moderate)
- Spironolactone + Olmesartan(moderate)
- Spironolactone + Valsartan(moderate)
- Spironolactone + Benazepril(minor)
- Spironolactone + Digoxin(minor)
- Spironolactone + Enalapril(minor)
- Spironolactone + Lisinopril(minor)
- Spironolactone + Potassium Chloride(minor)
- Spironolactone + Ramipril(minor)