Does Pravastatin Interact With Spironolactone?

Caution should also be exercised if a statin or other agent used to lower cholesterol levels is administered to patients also receiving other drugs (e.g., ketoconazole, spironolactone, cimetidine) that may diminish the levels or activity of steroid hormones.

Severity: Moderate

Severity basis: warnings section (keywords: caution). Combining Pravastatin (HMG-CoA reductase inhibitor (statin)) and Spironolactone (Potassium-sparing diuretic) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Caution should also be exercised if a statin or other agent used to lower cholesterol levels is administered to patients also receiving other drugs (e.g., ketoconazole, spironolactone, cimetidine) that may diminish the levels or activity of steroid hormones.

Source: FDA structured product labeling (set_id 01beb7e2-ba01-4f2f-8554-4a8ec0941c9f).

Pravastatin

HMG-CoA reductase inhibitor (statin)

Brands: Pravachol

View Pravastatin safety profile

Spironolactone

Potassium-sparing diuretic

Brands: Aldactone

View Spironolactone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

Questions About Your Medications?

A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.