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    HomeMedication GuideEnclomiphene Citrate safety
    Selective estrogen receptor modulator (SERM) — estrogen antagonistCompounded / Off-Label

    Enclomiphene: Patient Information & Safety Notes

    Also known as Androxal

    Other names: enclomifene, androxal, zuclomiphene

    Enclomiphene is the trans-isomer of clomiphene citrate. It acts as an estrogen receptor antagonist at the hypothalamic-pituitary level, blocking estrogen's negative feedback and thereby increasing LH and FSH output to stimulate testicular testosterone production. It is not independently FDA-approved for male hypogonadism.

    Enclomiphene (Androxal) received FDA Fast Track designation but has not received final FDA approval for male hypogonadism. It is available as a compounded preparation. This is not an FDA-approved indication. Clomiphene citrate (a mixture of enclomiphene and zuclomiphene) is FDA-approved for female infertility only.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What Enclomiphene Citrate is used for

    • Off-label/compounded: secondary hypogonadism in males (stimulates endogenous testosterone production while preserving fertility)

    Taking this medicine

    How it is administered

    • Oral capsule

    Read before you decide

    Risks and precautions

    Risks and warnings

    • Visual disturbances (class effect of clomiphene-related compounds; rare at low doses)
    • Mood changes
    • Gastrointestinal discomfort

    Who should not take it

    • Liver disease
    • Hormone-sensitive tumors
    • Pregnancy

    Common questions

    Patient questions

    Is enclomiphene better than testosterone injections for low T?

    Enclomiphene works differently: instead of replacing testosterone externally, it stimulates the body to produce its own. This preserves fertility and testicular function, which exogenous testosterone suppresses. The choice between approaches depends on individual goals and provider assessment. Enclomiphene is not FDA-approved for this use.

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    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Have medication questions?

    A licensed OmniRx provider can review your health history and medication list. Availability and treatment options are determined individually.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.