Gonadorelin: Patient Information & Safety Notes
Also known as GnRH, Factrel, Lutrepulse
Other names: gnrh, gonadotropin-releasing-hormone, factrel, lutrepulse
Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) that stimulates the pituitary to release LH and FSH. FDA-approved formulations have been used for fertility diagnostics and primary hypothalamic amenorrhea. Compounded gonadorelin is used off-label in male TRT to preserve testicular function.
In plain language
What Gonadorelin is used for
- Off-label/compounded: LH/FSH stimulation in males during testosterone replacement therapy
- Fertility support (male and female)
Taking this medicine
How it is administered
- Subcutaneous injection
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Risks and precautions
Risks and warnings
- Headache, nausea, flushing
- Injection site reactions
Who should not take it
- Hormone-sensitive cancers
- Pregnancy or breastfeeding
Common questions
Patient questions
How is gonadorelin used in testosterone replacement therapy?
Gonadorelin stimulates the pituitary to produce LH and FSH, which signal the testes to produce testosterone and sperm. Some providers use it as an alternative or adjunct to HCG to maintain testicular function during exogenous testosterone therapy. This is an off-label use of a compounded preparation.
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Sources & References
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