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    HomeMedication GuideChorionic Gonadotropin safety
    Gonadotropin hormoneFDA-Approved

    HCG (Human Chorionic Gonadotropin): Patient Information & Safety Notes

    Also known as HCG, Pregnyl, Novarel

    Other names: human-chorionic-gonadotropin, pregnyl, novarel

    Human chorionic gonadotropin (HCG) is an FDA-approved gonadotropin hormone used in reproductive medicine and to treat hypogonadism in males. It acts on the same receptor as luteinizing hormone (LH) to stimulate testosterone production in the testes and support spermatogenesis.

    FDA-approved products have indications that include female infertility, selected cases of male hypogonadism, and prepubertal cryptorchidism. Injectable HCG requires a prescription. Compounded HCG products are not FDA-approved and are subject to compounding restrictions.
    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    In plain language

    What Chorionic Gonadotropin is used for

    • Male hypogonadism (stimulates endogenous testosterone production)
    • Fertility support in males (spermatogenesis support)
    • Female ovulation induction (reproductive medicine)

    Taking this medicine

    How it is administered

    • Subcutaneous injection (after reconstitution)

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    Risks and precautions

    Risks and warnings

    • Gynecomastia (breast tissue enlargement in males)
    • Injection site irritation
    • Nausea
    • Ovarian hyperstimulation syndrome (females, serious risk)

    Who should not take it

    • Hormone-sensitive cancers (prostate cancer, testosterone-sensitive cancers)
    • History of venous thromboembolism (blood clots)
    • Pregnancy (females — not for use during pregnancy)

    Common questions

    Patient questions

    Why is HCG used with testosterone replacement therapy?

    Exogenous testosterone suppresses the natural signaling that stimulates testicular testosterone production and sperm formation. HCG mimics LH and can maintain testicular function, size, and fertility during testosterone therapy. A provider monitors levels to guide appropriate use.

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    Testosterone Therapy

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Have medication questions?

    A licensed OmniRx provider can review your health history and medication list. Availability and treatment options are determined individually.

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.