Does Allopurinol Interact With Amoxicillin Clavulanate?
( 7.1 ) Concomitant use of AUGMENTIN and oral anticoagulants may increase the prolongation of prothrombin time.( 7.2 ) Co-administration with allopurinol increases the risk of rash.
Severity: Moderate
Severity basis: drug interactions section (keywords: may increase). Combining Allopurinol (Xanthine oxidase inhibitor) and Amoxicillin Clavulanate (Penicillin/beta-lactamase inhibitor antibiotic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Allopurinol is a xanthine oxidase inhibitor and Amoxicillin Clavulanate is a penicillin/beta-lactamase inhibitor antibiotic; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Allopurinol and Amoxicillin Clavulanate, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
( 7.1 ) Concomitant use of AUGMENTIN and oral anticoagulants may increase the prolongation of prothrombin time.( 7.2 ) Co-administration with allopurinol increases the risk of rash.
Source: FDA structured product labeling (set_id 04a31a42-d79e-bbb4-e063-6394a90a63ee).
Amoxicillin Clavulanate
Penicillin/beta-lactamase inhibitor antibiotic
Brands: Augmentin
View Amoxicillin Clavulanate safety profileCheck these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Allopurinol and Amoxicillin Clavulanate together?
Allopurinol and Amoxicillin Clavulanate have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Allopurinol and Amoxicillin Clavulanate interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: may increase). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Allopurinol and Amoxicillin Clavulanate?
If you have been prescribed both Allopurinol and Amoxicillin Clavulanate, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.