Does Allopurinol Interact With Amoxicillin Clavulanate?
( 7.1 ) Concomitant use of AUGMENTIN and oral anticoagulants may increase the prolongation of prothrombin time.( 7.2 ) Co-administration with allopurinol increases the risk of rash.
Severity: Moderate
Severity basis: drug interactions section (keywords: may increase). Combining Allopurinol (Xanthine oxidase inhibitor) and Amoxicillin Clavulanate (Penicillin/beta-lactamase inhibitor antibiotic) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
( 7.1 ) Concomitant use of AUGMENTIN and oral anticoagulants may increase the prolongation of prothrombin time.( 7.2 ) Co-administration with allopurinol increases the risk of rash.
Source: FDA structured product labeling (set_id 04a31a42-d79e-bbb4-e063-6394a90a63ee).
Amoxicillin Clavulanate
Penicillin/beta-lactamase inhibitor antibiotic
Brands: Augmentin
View Amoxicillin Clavulanate safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.