Does Allopurinol Interact With Colchicine?
Concurrent prophylactic treatment with colchicine or anti-inflammatory agents is recommended.
Severity: Minor
Severity basis: warnings section. Combining Allopurinol (Xanthine oxidase inhibitor) and Colchicine (Anti-gout agent) is classified as a minor interaction.
What to Do
This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.
From the FDA Label
Concurrent prophylactic treatment with colchicine or anti-inflammatory agents is recommended.
Source: FDA structured product labeling (set_id 005048dd-844f-468c-bf56-1a09727e3477).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Allopurinol Interactions
Other Colchicine Interactions
- Colchicine + Clarithromycin(contraindicated)
- Colchicine + Itraconazole(contraindicated)
- Colchicine + Atorvastatin(moderate)
- Colchicine + Cyclosporine(moderate)
- Colchicine + Fenofibrate(moderate)
- Colchicine + Gemfibrozil(moderate)
- Colchicine + Lovastatin(moderate)
- Colchicine + Pravastatin(moderate)
- Colchicine + Simvastatin(moderate)
- Colchicine + Azithromycin(minor)
- Colchicine + Digoxin(minor)
- Colchicine + Diltiazem(minor)
- Colchicine + Estradiol(minor)
- Colchicine + Ketoconazole(minor)
- Colchicine + Rosuvastatin(minor)
- Colchicine + Verapamil(minor)