Does Amitriptyline Interact With Topiramate?

Drug Interactions Topiramate Some patients may experience a large increase in amitriptyline concentration in the presence of topiramate and any adjustments in amitriptyline dose should be made according to the patient's clinical response and not on the basis of plasma levels.

Severity: Minor

Severity basis: drug interactions section. Combining Amitriptyline (Tricyclic antidepressant) and Topiramate (Anticonvulsant) is classified as a minor interaction.

What to Do

This is generally a minor interaction, but review it with your pharmacist to be sure it is safe for you.

From the FDA Label

Drug Interactions Topiramate Some patients may experience a large increase in amitriptyline concentration in the presence of topiramate and any adjustments in amitriptyline dose should be made according to the patient's clinical response and not on the basis of plasma levels.

Source: FDA structured product labeling (set_id 0067b698-ee1d-4524-b1cc-af1028d13736).

Amitriptyline

Tricyclic antidepressant

Brands: Elavil

View Amitriptyline safety profile

Topiramate

Anticonvulsant

Brands: Topamax, Qudexy XR

View Topiramate safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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