Does Amitriptyline Interact With Risperidone?

Dose adjustment is not recommended for risperidone tablets when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin [see Table 18 ] .

Severity: Major

Severity basis: drug interactions section (keywords: not recommended). Combining Amitriptyline (Tricyclic antidepressant) and Risperidone (Atypical antipsychotic) is classified as a major interaction.

What to Do

The label advises avoiding this combination or using it only under close medical supervision. Talk to your prescriber or pharmacist before combining them.

From the FDA Label

Dose adjustment is not recommended for risperidone tablets when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin [see Table 18 ] .

Source: FDA structured product labeling (set_id 03d3b52d-3a7d-4595-84c9-332da6ca9171).

Amitriptyline

Tricyclic antidepressant

Brands: Elavil

View Amitriptyline safety profile

Risperidone

Atypical antipsychotic

Brands: Risperdal

View Risperidone safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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