Does Amitriptyline Interact With Cyclobenzaprine?
Cyclobenzaprine is closely related to the tricyclic antidepressants, e.g., amitriptyline and imipramine.
Severity: Moderate
Severity basis: warnings section (keywords: closely). Combining Amitriptyline (Tricyclic antidepressant) and Cyclobenzaprine (Skeletal muscle relaxant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Amitriptyline is a tricyclic antidepressant and Cyclobenzaprine is a skeletal muscle relaxant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Amitriptyline and Cyclobenzaprine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Cyclobenzaprine is closely related to the tricyclic antidepressants, e.g., amitriptyline and imipramine.
Source: FDA structured product labeling (set_id 00b20a8c-debd-e930-e063-6394a90a7ed0).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Amitriptyline and Cyclobenzaprine together?
Amitriptyline and Cyclobenzaprine have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Amitriptyline and Cyclobenzaprine interaction?
It is classified as a moderate interaction, based on the FDA label's warnings section (keywords: closely). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Amitriptyline and Cyclobenzaprine?
If you have been prescribed both Amitriptyline and Cyclobenzaprine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Amitriptyline Interactions
- Amitriptyline + Risperidone(major)
- Amitriptyline + Carbamazepine(moderate)
- Amitriptyline + Duloxetine(moderate)
- Amitriptyline + Levothyroxine(moderate)
- Amitriptyline + Liothyronine(moderate)
- Amitriptyline + Valproic Acid(moderate)
- Amitriptyline + Clonidine(minor)
- Amitriptyline + Fluconazole(minor)
- Amitriptyline + Fluoxetine(minor)
- Amitriptyline + Paroxetine(minor)
- Amitriptyline + Sertraline(minor)
- Amitriptyline + Topiramate(minor)