Does Amlodipine Interact With Tacrolimus?

Immunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered.

Severity: Moderate

Severity basis: drug interactions section (keywords: may increase). Combining Amlodipine (Calcium channel blocker) and Tacrolimus (Calcineurin inhibitor immunosuppressant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Immunosuppressants Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered.

Source: FDA structured product labeling (set_id 003dd1ec-16f8-4f96-b6a8-c4689d35892a).

Amlodipine

Calcium channel blocker

Brands: Norvasc

View Amlodipine safety profile

Tacrolimus

Calcineurin inhibitor immunosuppressant

Brands: Prograf, Astagraf XL

View Tacrolimus safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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