Does Metoclopramide Interact With Tacrolimus?
Other drugs, such as: Magnesium and aluminum hydroxide antacids Metoclopramide May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Severity: Moderate
Severity basis: drug interactions section (keywords: caution, may increase). Combining Metoclopramide (Prokinetic / antiemetic) and Tacrolimus (Calcineurin inhibitor immunosuppressant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Other drugs, such as: Magnesium and aluminum hydroxide antacids Metoclopramide May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Source: FDA structured product labeling (set_id 08cf2861-2483-405d-a872-a88a5c235f9a).
Tacrolimus
Calcineurin inhibitor immunosuppressant
Brands: Prograf, Astagraf XL
View Tacrolimus safety profileCheck these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Metoclopramide Interactions
Other Tacrolimus Interactions
- Tacrolimus + Amiodarone(moderate)
- Tacrolimus + Amlodipine(moderate)
- Tacrolimus + Carbamazepine(moderate)
- Tacrolimus + Clarithromycin(moderate)
- Tacrolimus + Diltiazem(moderate)
- Tacrolimus + Estradiol(moderate)
- Tacrolimus + Fluconazole(moderate)
- Tacrolimus + Itraconazole(moderate)
- Tacrolimus + Ketoconazole(moderate)
- Tacrolimus + Lansoprazole(moderate)
- Tacrolimus + Methylprednisolone(moderate)
- Tacrolimus + Nifedipine(moderate)
- Tacrolimus + Omeprazole(moderate)
- Tacrolimus + Phenytoin(moderate)
- Tacrolimus + Prednisone(moderate)
- Tacrolimus + Rifampin(moderate)
- Tacrolimus + Verapamil(moderate)
- Tacrolimus + Cyclosporine(minor)
- Tacrolimus + Fenofibrate(minor)
- Tacrolimus + Fluoxetine(minor)