Does Prednisone Interact With Tacrolimus?

Mild or Moderate CYP3A Inducers Methylprednisolone, prednisone May decrease tacrolimus whole blood trough concentrations.

Severity: Moderate

Severity basis: drug interactions section (keywords: may decrease). Combining Prednisone (Systemic corticosteroid) and Tacrolimus (Calcineurin inhibitor immunosuppressant) is classified as a moderate interaction.

What to Do

Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

From the FDA Label

Mild or Moderate CYP3A Inducers Methylprednisolone, prednisone May decrease tacrolimus whole blood trough concentrations.

Source: FDA structured product labeling (set_id 08cf2861-2483-405d-a872-a88a5c235f9a).

Prednisone

Systemic corticosteroid

Brands: Deltasone, Rayos

View Prednisone safety profile

Tacrolimus

Calcineurin inhibitor immunosuppressant

Brands: Prograf, Astagraf XL

View Tacrolimus safety profile

Check these against your full medication list in our free Interaction Checker

This information is educational — not medical advice.

This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

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