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    HomeMedication GuideDrug InteractionsFluconazole + Tacrolimus
    Moderate interaction

    Does Fluconazole Interact With Tacrolimus?

    (See PRECAUTIONS .) Tacrolimus: There have been published reports that an interaction exists when fluconazole is administered concomitantly with tacrolimus, leading to increased serum levels of tacrolimus.

    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    Severity: Moderate

    Severity basis: drug interactions section (keywords: caution). Combining Fluconazole (Azole antifungal) and Tacrolimus (Calcineurin inhibitor immunosuppressant) is classified as a moderate interaction.

    What to Do

    Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How This Interaction Works

    Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Fluconazole is a azole antifungal and Tacrolimus is a calcineurin inhibitor immunosuppressant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

    If You Take Both Medications

    If you have been prescribed both Fluconazole and Tacrolimus, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    From the FDA Label

    (See PRECAUTIONS .) Tacrolimus: There have been published reports that an interaction exists when fluconazole is administered concomitantly with tacrolimus, leading to increased serum levels of tacrolimus.

    Source: FDA structured product labeling (set_id 01df20c4-7b94-044e-e063-6394a90a406a).

    Fluconazole

    Azole antifungal

    Brands: Diflucan

    View Fluconazole safety profile

    Tacrolimus

    Calcineurin inhibitor immunosuppressant

    Brands: Prograf, Astagraf XL

    View Tacrolimus safety profile

    Check these against your full medication list in our free Interaction Checker

    Frequently Asked Questions

    Can you take Fluconazole and Tacrolimus together?

    Fluconazole and Tacrolimus have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How serious is the Fluconazole and Tacrolimus interaction?

    It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: caution). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

    What should I do if I'm taking both Fluconazole and Tacrolimus?

    If you have been prescribed both Fluconazole and Tacrolimus, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

    A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

    Other Fluconazole Interactions

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.