Does Aripiprazole Interact With Desvenlafaxine?
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Severity: Moderate
Severity basis: drug interactions section (keywords: dosage adjustment). Combining Aripiprazole (Atypical antipsychotic) and Desvenlafaxine (SNRI antidepressant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How This Interaction Works
Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Aripiprazole is a atypical antipsychotic and Desvenlafaxine is a snri antidepressant; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.
If You Take Both Medications
If you have been prescribed both Aripiprazole and Desvenlafaxine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
From the FDA Label
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Source: FDA structured product labeling (set_id 0f43610c-f290-46ea-d186-4f998ed99fce).
Check these against your full medication list in our free Interaction Checker
Frequently Asked Questions
Can you take Aripiprazole and Desvenlafaxine together?
Aripiprazole and Desvenlafaxine have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
How serious is the Aripiprazole and Desvenlafaxine interaction?
It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: dosage adjustment). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.
What should I do if I'm taking both Aripiprazole and Desvenlafaxine?
If you have been prescribed both Aripiprazole and Desvenlafaxine, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Aripiprazole Interactions
- Aripiprazole + Carbamazepine(moderate)
- Aripiprazole + Clarithromycin(moderate)
- Aripiprazole + Escitalopram(moderate)
- Aripiprazole + Famotidine(moderate)
- Aripiprazole + Fluoxetine(moderate)
- Aripiprazole + Itraconazole(moderate)
- Aripiprazole + Lamotrigine(moderate)
- Aripiprazole + Lithium(moderate)
- Aripiprazole + Omeprazole(moderate)
- Aripiprazole + Paroxetine(moderate)
- Aripiprazole + Sertraline(moderate)
- Aripiprazole + Valproic Acid(moderate)
- Aripiprazole + Venlafaxine(moderate)
- Aripiprazole + Warfarin(moderate)
- Aripiprazole + Lorazepam(minor)
- Aripiprazole + Quetiapine(minor)
- Aripiprazole + Rifampin(minor)