Does Atomoxetine Interact With Desvenlafaxine?
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Severity: Moderate
Severity basis: drug interactions section (keywords: dosage adjustment). Combining Atomoxetine (Non-stimulant ADHD agent) and Desvenlafaxine (SNRI antidepressant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Source: FDA structured product labeling (set_id 0f43610c-f290-46ea-d186-4f998ed99fce).
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This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Atomoxetine Interactions
- Atomoxetine + Fluoxetine(moderate)
- Atomoxetine + Paroxetine(moderate)
- Atomoxetine + Albuterol(minor)
- Atomoxetine + Aspirin(minor)
- Atomoxetine + Celecoxib(minor)
- Atomoxetine + Diazepam(minor)
- Atomoxetine + Methylphenidate(minor)
- Atomoxetine + Omeprazole(minor)
- Atomoxetine + Phenytoin(minor)
- Atomoxetine + Warfarin(minor)