Patient Portal
    Text START to:+1 (770) 243-5753
    Trusted by over 10K subscribers
    Free & discreet shipping on all prescriptions
    Affordable pricing with no hidden fees
    FDA-regulated pharmacies
    100% online process
    Trusted by over 10K subscribers
    Free & discreet shipping on all prescriptions
    Affordable pricing with no hidden fees
    FDA-regulated pharmacies
    100% online process
    Trusted by over 10K subscribers
    Free & discreet shipping on all prescriptions
    Affordable pricing with no hidden fees
    FDA-regulated pharmacies
    100% online process
    HomeMedication GuideDrug InteractionsAripiprazole + Clarithromycin
    Moderate interaction

    Does Aripiprazole Interact With Clarithromycin?

    7 DRUG INTERACTIONS Dosage adjustment due to drug interactions (7.1): Factors Dosage Adjustments for Aripiprazole Known CYP2D6 Poor Metabolizers Administer half of usual dose Known CYP2D6 Poor Metabolizers and strong CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP2D6 or CYP3A4 inhibitors Administer half of usual dose Strong CYP2D6 and CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP3A4 inducers Double usual dose over 1 to 2 weeks 7.1 Drugs Having Clinically Impo…

    Reviewed by the OmniRx Health clinical team•Last reviewed Jul 4, 2026

    Severity: Moderate

    Severity basis: drug interactions section (keywords: dosage adjustment). Combining Aripiprazole (Atypical antipsychotic) and Clarithromycin (Macrolide antibiotic) is classified as a moderate interaction.

    What to Do

    Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How This Interaction Works

    Interactions like this one can happen when two medicines have overlapping effects, or when one changes how the other is absorbed, broken down, or cleared from the body. Aripiprazole is a atypical antipsychotic and Clarithromycin is a macrolide antibiotic; together they are documented as a moderate interaction. How much this matters depends on your dose, your other medications, and your overall health.

    If You Take Both Medications

    If you have been prescribed both Aripiprazole and Clarithromycin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    From the FDA Label

    7 DRUG INTERACTIONS Dosage adjustment due to drug interactions (7.1): Factors Dosage Adjustments for Aripiprazole Known CYP2D6 Poor Metabolizers Administer half of usual dose Known CYP2D6 Poor Metabolizers and strong CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP2D6 or CYP3A4 inhibitors Administer half of usual dose Strong CYP2D6 and CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP3A4 inducers Double usual dose over 1 to 2 weeks 7.1 Drugs Having Clinically Impo…

    Source: FDA structured product labeling (set_id 02a4af27-c83c-4166-950c-7a1cb12d198d).

    Aripiprazole

    Atypical antipsychotic

    Brands: Abilify

    View Aripiprazole safety profile

    Clarithromycin

    Macrolide antibiotic

    Brands: Biaxin

    View Clarithromycin safety profile

    Check these against your full medication list in our free Interaction Checker

    Frequently Asked Questions

    Can you take Aripiprazole and Clarithromycin together?

    Aripiprazole and Clarithromycin have a documented moderate interaction. Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.

    How serious is the Aripiprazole and Clarithromycin interaction?

    It is classified as a moderate interaction, based on the FDA label's drug interactions section (keywords: dosage adjustment). A moderate interaction can be clinically meaningful and usually calls for monitoring or a dose adjustment.

    What should I do if I'm taking both Aripiprazole and Clarithromycin?

    If you have been prescribed both Aripiprazole and Clarithromycin, do not start, stop, or change either medication on your own — some medicines are unsafe to stop suddenly. Tell your prescriber and pharmacist that you take both so they can decide whether the combination is right for you, adjust the dose, monitor you more closely, or suggest an alternative.

    This information is educational — not medical advice.

    This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.

    Questions About Your Medications?

    A licensed OmniRx provider can review your full medication list and help you understand what's safe for you — no office visit required.

    Other Clarithromycin Interactions

    Sources & References

    Learn more about where our data comes from and how we write and review medical content.