Does Aripiprazole Interact With Escitalopram?
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Severity: Moderate
Severity basis: drug interactions section (keywords: dosage adjustment). Combining Aripiprazole (Atypical antipsychotic) and Escitalopram (SSRI antidepressant) is classified as a moderate interaction.
What to Do
Use this combination with caution. Your prescriber may monitor you more closely or adjust doses.
From the FDA Label
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Source: FDA structured product labeling (set_id 02a4af27-c83c-4166-950c-7a1cb12d198d).
Check these against your full medication list in our free Interaction Checker
This information is educational — not medical advice.
This page is provided for general educational purposes and summarizes publicly available data from sources such as the U.S. Food & Drug Administration. It is not a substitute for the judgment of a licensed clinician and should not be used to start, stop, or change any medication. It may be incomplete or out of date, and individual circumstances vary. Always talk with your prescriber or pharmacist about your specific medications and health conditions. If you think you may have a medical emergency, call 911.
Other Aripiprazole Interactions
- Aripiprazole + Carbamazepine(moderate)
- Aripiprazole + Clarithromycin(moderate)
- Aripiprazole + Desvenlafaxine(moderate)
- Aripiprazole + Famotidine(moderate)
- Aripiprazole + Fluoxetine(moderate)
- Aripiprazole + Itraconazole(moderate)
- Aripiprazole + Lamotrigine(moderate)
- Aripiprazole + Lithium(moderate)
- Aripiprazole + Omeprazole(moderate)
- Aripiprazole + Paroxetine(moderate)
- Aripiprazole + Sertraline(moderate)
- Aripiprazole + Valproic Acid(moderate)
- Aripiprazole + Venlafaxine(moderate)
- Aripiprazole + Warfarin(moderate)
- Aripiprazole + Lorazepam(minor)
- Aripiprazole + Quetiapine(minor)
- Aripiprazole + Rifampin(minor)